Reducer Publications Compendium


Coronary sinus reducer for the treatment of chronic refractory angina pectoris?results of the preclinical safety and feasibility study
Catheterization and Cardiovascular Interventions

Maayan Konigstein MD, Rona Shofti DVM, PhD, Marc Schwartz RCIS, Shmuel Banai MD
Published September 2018



Coronary Sinus Reducer Stent for the Treatment of Chronic Refractory Angina Pectoris

A Prospective, Open-Label, Multicenter, Safety Feasibility First-in-Man Study
Journal of the American College of Cardiology

Shmuel Banai, Shmuel Ben Muvhar, Keyur H. Parikh, Aharon Medina, Horst Sievert, Ashok Seth, Jonathan Tsehori, Yoav Paz, Ami Sheinfeld and Gad Keren
Published May 2007
PDF Article


First-in-Human Use of Coronary Sinus Reducer in Patients With Refractory Angina
Journal of the American College of Cardiology

Parth Parikh, Parloop Bhatt, Deepa Shah, Piyush Thakar, Ajay Naik, Hemang Baxi, Shmuel Banai and Keyur Parikh
Published December 2018

PDF Article


Multicenter Randomized Sham-Controlled Clinical Trial

A phase II, sham-controlled, double-blinded study testing the safety and efficacy of the coronary sinus reducer in patients with refractory angina: study protocol for a randomized controlled trial

E Marc Jolicœur, Shmuel Banai, Timothy D Henry, Marc Schwartz, Serge Doucet, Christopher J White, Elazer Edelman and Stefan Verheye
Published February 2013


Efficacy of a Device to Narrow the Coronary Sinus in Refractory Angina
New England Journal of Medicine

Stefan Verheye, M.D., Ph.D., E. Marc Jolicœur, M.D., Miles W. Behan, M.D., Thomas Pettersson, M.D., Paul Sainsbury, M.D., Jonathan Hill, M.D., Mathias Vrolix, M.D., Pierfrancesco Agostoni, M.D., Thomas Engstrom, M.D., Marino Labinaz, M.D., Ranil de Silva, M.D., Marc Schwartz, R.C.I.S., Nathalie Meyten, M.D., Neal G. Uren, M.D., Serge Doucet, M.D., Jean-François Tanguay, M.D., Steven Lindsay, M.D., Timothy D. Henry, M.D., Christopher J. White, M.D., Elazer R. Edelman, M.D., Ph.D., and Shmuel Banai, M.D.
Published February 2015


Clinical Reports and Clinical Experience

Transcatheter treatment for refractory angina with the coronary sinus Reducer

Maayan Konigstein, MD; Nathalie Meyten, MD; Stefan Verheye, MD; Marc Schwartz, RCIS; Shmuel Banai, MD
Published February 2014


Coronary sinus reducer device for patients with refractory angina
Cardiovascular Medicine

Peter C. Kahr, Andreas A. Giannopoulos, Ronny R. Buechel, Oliver Gaemperli, Shmuel Banai, Slayman Obeid, Thomas F. Lüscher
Published:  April 2018


Coronary Sinus Reducer implantation improves symptoms, ischaemia and physical capacity in patients with refractory angina unsuitable for myocardial revascularization: a single-center experience

Maayan Konigstein, MD; Samuel Bazan, MD; Miri Revivo, MHA; Shmuel Banai, MD
Published July 2018
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Coronary Sinus Reducer Implantation for the Treatment of Chronic Refractory Angina – A Single-Center Experience
JACC: Cardiovascular Interventions

Francesco Giannini, Luca Baldetti, Francesco Ponticelli, Neil Ruparelia, Satoru Mitomo, Azeem Latib, Matteo Montorfano, Richard J. Jabbour, Andrea Aurelio, Luca Ferri, Antonio Mangieri, Damiano Regazzoli, Marco Ancona, Matteo Pagnesi, Alessia Faccini, Alaide Chieffo, Lorenzo Azzalini, Mauro Carlino and Antonio Colombo
Published April 2018
PDF Article


Intermittent Coronary Sinus Occlusion After Coronary Arterial Ligation Results in Venous Retroperfusion
Circulation Research

Rafael Beyar, Alan D. Guerci, Henry R. Halperin, Joshua E. Tsitlik, and Myron L. Weisfeldt
Published September 1989


Coronary sinus perforation during reducer implantation (Abstract)
Catheterization Cardiovascular Interventions

Bernardo Cortese MD, Gaetano di Palma MD, Roberto Latini MD
Published February 2018


The coronary sinus Reducer device for refractory chronic angina: rationale, clinical evidence and future perspectives (Editorial)
Expert Review of Medical Devices

Rocco A. Montone, Michele Russo, Francesco Giannini & Giampaolo Niccoli
Published September 2018


Can we implant left ventricle pacing lead in a patient with coronary sinus reducer?
Journal of Interventional Cardiac Electrophysiology

Luca Bontempi, Francesca Vassanelli, Manuel Cerini, Lorenza Inama, Francesca Salghetti, Daniele Giacopelli, Antonio Curnis
Published January 2018


Coronary sinus reducer non-responders: insights and perspectives

Luca Baldetti, MD; Antonio Colombo, MD; Shmuel Banai, MD; Azeem Latib, MD; Antonio Esposito, MD; Anna Palmisano, MD; Francesco Giannini, MD
Published February 2018


Reducer, extracorporeal shockwave therapy or stem cells in refractory angina: a retrospective study
Journal of Cardiovascular Medicine

Slavich, Massimo; Giannini, Francesco; Godino, Cosmo; Pizzetti, Giuseppe; Gramegna, Mario; Fragasso, Gabriele; Margonato, Alberto
Published January 2018,_extracorporeal_shockwave_therapy_or_stem.10.aspx


First Experience With the Coronary Sinus Reducer System for the Management of Refractory Angina in Patients Without Obstructive Coronary Artery Disease
JACC: Cardiovascular Interventions- Research Correspondence

Francesco Giannini, Luca Baldetti, Alfonso Ielasi, Neil Ruparelia, Francesco Ponticelli, Azeem Latib, Satoru Mitomo, Antonio Esposito, Anna Palmisano, Alaide Chieffo and Antonio Colombo
Published September 2017
PDF Article


Implantation of the Reducer device in the coronary sinus: a new treatment for refractory angina
Giornale Italiano di Cardiologia

Francesco Giannini, Andrea Aurelio, Alaide Chieffo
Published October 2016


Safety and efficacy of a device to narrow the coronary sinus for the treatment of refractory angina: A single-centre real-world experience (Abstract)
Netherlands Heart Journal

Abawi, F. Nijhoff, P.R. Stella, M. Voskuil, D. Benedetto, P.A. Doevendans, and P. Agostoni
Published June 2016
DOI:  10.1007/s12471-016-0862-2


Coronary Sinus Reducer improves angina and ischaemia by redistribution of blood from non-ischaemic to ischaemic myocardium (Abstract)


Konigstein M, Meyten N, Verheye S, Schwartz M, Banai S
Published October 2015


Innovative therapies for the treatment of refractory angina: the Reducer, a percutaneous device for narrowing the venous coronary sinus
Giornale Italiano di Cardiologia

Daniela Benedetto, Masieh Abawi, Pieter R. Star, Freek Nijhoff, Pierfrancesco Agostoni
Published November 2015


Transcatheter treatment for refractory angina with the coronary sinus Reducer

Maayan Konigstein, MD; Nathalie Meyten, MD; Stefan Verheye, MD; Marc Schwartz, RCIS; Shmuel Banai, MD
Published February 2014


Coronary Sinus Reducer Implantation
Potential New Horizons Where it Should Be Tested
JACC Cardiovascular Interventions- Letter to the Editor

Iñigo Lozano, Esmeralda Capin, Dae-Hyun Lee Hwang, Ramon Lopez-Palop and Eduardo Segovia
Published August 2018


Unusual Implantation of a Coronary Sinus Reducer in the Middle Cardiac Vein
Journal of Invasive Cardiology

Riccardo Gorla, MD, PhD; Francesco Giannini, MD; Francesco Bedogni, MD; Federico De Marco, MD, PhD
Published August 2018


Coronary sinus reducer for the treatment of refractory angina
International Journal of Cardiology

Ouyang F, He Y, Guo S, Wang C, Liu W, Guo Y
Published February 2019


First-in-Human Use of Coronary Sinus Reducer in Patients With Refractory Angina
Journal of the American College of Cardiology

Parikh P, Bhatt P, Shah D, Thakar P, Naik A, Baxi H, Banai S, Parikh K.
Published December 2018


The coronary sinus Reducer: a new opportunity for refractory angina. Comparison between Italian experiences
Giornale Italiano di Cardiologia

Tebaldi M, Bertini M, Ielasi A, Erriquez A, Baldetti L, Passarini G, Tespili M, Gallone G, Giannini F.
Published December 2018


Percutaneous management of periprocedural coronary sinus Reducer migration
Catheterization Cardiovascular Interventions

Tzanis G, Durante A, Mitomo S, Giannini F.
Published November 2018


Coronary Sinus Reducer Implantation to Reduce the Ischemic Burden in Refractory Angina
JACC: Cardiovascular Interventions

Guglielmo Gallone, Luca Baldetti, Anna Palmisano, Francesco Ponticelli, Georgios Tzanis, Antonio Colombo, Antonio Esposito and Francesco Giannini
November 2018
PDF Article


“Angina pectoris? A new method for patients with circulatory disorders of the heart “

Herz Heute
Prof. Tanja Rudolph
Published February 2019


Angina and left ventricular dysfunction: can we ‘reduce’ it?

European Society of Cardiology

Simone Biscaglia, Matteo Tebaldi, Donato Mele, Cristina Balla, and Roberto Ferrari
Published April 2019


The coronary sinus reducer: a validate option for “no-option” labeled patients. Clinical evidences and new perspectives

Revista Argentina de Cardioangiología Intervencionista

Michele Bellamoli, Carlo Zivelonghi, Federico Marin, Flavio L. Ribichini, Stefan Verheye, Pierfrancesco Agostoni
Published March 2019



The Reducer device in patients with angina pectoris: mechanisms, indications, and perspectives
European Heart Journal

Maayan Konigstein, Francesco Giannini, Shmuel Banai


The efficacy of coronary sinus reducer in patients with refractory angina—A systematic review of the literature
Journal of Interventional Cardiology

George Bazoukis MD, MSc, Emmanouil S. Brilakis MD, PhD, Gary Tse MD, PhD, Konstantinos P. Letsas MD, PhD, Panagiotis Kitsoulis MD, PhD, Tong Liu MD, PhD, Adrian Baranchuk MD, PhD, Antonios Sideris MD, Costas Tsioufis MD, PhD, Stavros Stavrakis MD, PhD
Published September 2018


The coronary sinus reducer: clinical evidence and technical aspects
Expert Review of Cardiovascular Therapy

Francesco Giannini, Andrea Aurelio, Richard J. Jabbour, Luca Ferri, Antonio Colombo, & Azeem Latib
Published January 2017


Coronary Sinus Reducer system™: A new therapeutic option in refractory angina patients unsuitable for revascularization
International Journal of Cardiology

Alfonso Lelasi, Maria Chiara Todaro, Giulietta Grigis, Maurizio Tespili
Published April 2016


Coronary Sinus Stent: Could It Help in Refractory Chronic Stable Angina?
Current Cardiology Reports

Wael ElMallah
Published April 2016


Percutaneous Device to Narrow the Coronary Sinus: Shifting Paradigm in the Treatment of Refractory Angina? A Review of the Literature
Frontiers in Cardiovascular Medicine

Daniela Benedetto, Masieh Abawi, Pieter R. Stella, Freek Nijhoff, Maxime D. M. Lakemeier, Friso Kortlandt, Pieter A. Doevendans, and Pierfrancesco Agostoni
Published October 2016



Harefuah Konigstein, M; Banai S.
Published July 2017

In Press

Myocardial Ischemia Amelioration Reducing Venous Outflow
Revista Española de Cardiología

Zamora E., Teis A., Rodriguez O.
Published November 2018 (available online)


The impact of coronary sinus narrowing on diastolic function in patients with refractory angina
International Journal of Cardiology

Yishay Szekely, Yan Topilsky, Samuel Bazan, Miri Revivo, Shmuel Banai, Maayan Konigstein
Published March 2019 (available online)


Safety and efficacy of Coronary Sinus Reducer implantation at 2-year follow-up
International Journal of Cardiology

Francesco Ponticellia, Giorgos Tzanisa, Guglielmo Galloneb, Luca Baldettia, Antonio Mangieric, Antonio Colombo, Francesco Giannini
Published May 2019 (available online)