The Neovasc ReducerTM Publications Library
Pre-Clinical
Coronary sinus reducer for the treatment of chronic refractory angina pectoris?results of the preclinical safety and feasibility study
Catheterization and Cardiovascular Interventions
Maayan Konigstein MD, Rona Shofti DVM, PhD, Marc Schwartz RCIS, Shmuel Banai MD
Published September 2018
https://doi.org/10.1002/ccd.27709
First-In-Human
Coronary Sinus Reducer Stent for the Treatment of Chronic Refractory Angina Pectoris
A Prospective, Open-Label, Multicenter, Safety Feasibility First-in-Man Study
Journal of the American College of Cardiology
Shmuel Banai, Shmuel Ben Muvhar, Keyur H. Parikh, Aharon Medina, Horst Sievert, Ashok Seth, Jonathan Tsehori, Yoav Paz, Ami Sheinfeld and Gad Keren
Published May 2007 DOI: 10.1016/j.jacc.2007.01.061
PDF Article
First-in-Human Use of Coronary Sinus Reducer in Patients With Refractory Angina
Journal of the American College of Cardiology
Parth Parikh, Parloop Bhatt, Deepa Shah, Piyush Thakar, Ajay Naik, Hemang Baxi, Shmuel Banai and Keyur Parikh
Published December 2018 DOI: 10.1016/j.jacc.2018.09.061
Multicenter randomized sham-controlled clinical trial
A phase II, sham-controlled, double-blinded study testing the safety and efficacy of the coronary sinus reducer in patients with refractory angina: study protocol for a randomized controlled trial
Trials
E Marc Jolicœur, Shmuel Banai, Timothy D Henry, Marc Schwartz, Serge Doucet, Christopher J White, Elazer Edelman and Stefan Verheye
Published February 2013
https://doi.org/10.1186/1745-6215-14-46
Efficacy of a Device to Narrow the Coronary Sinus in Refractory Angina
New England Journal of Medicine
Stefan Verheye, M.D., Ph.D., E. Marc Jolicœur, M.D., Miles W. Behan, M.D., Thomas Pettersson, M.D., Paul Sainsbury, M.D., Jonathan Hill, M.D., Mathias Vrolix, M.D., Pierfrancesco Agostoni, M.D., Thomas Engstrom, M.D., Marino Labinaz, M.D., Ranil de Silva, M.D., Marc Schwartz, R.C.I.S., Nathalie Meyten, M.D., Neal G. Uren, M.D., Serge Doucet, M.D., Jean-François Tanguay, M.D., Steven Lindsay, M.D., Timothy D. Henry, M.D., Christopher J. White, M.D., Elazer R. Edelman, M.D., Ph.D., and Shmuel Banai, M.D.
Published February 2015
https://www.nejm.org/doi/full/10.1056/NEJMoa1402556
Clinical reports and clinical experience
Transcatheter treatment for refractory angina with the coronary sinus Reducer
EuroIntervention
Maayan Konigstein¹, MD; Nathalie Meyten², MD; Stefan Verheye², MD; Marc Schwartz3, RCIS; Shmuel Banai, MD
Published February 2014
https://www.researchgate.net/publication/260374743_Transcatheter_treatment_for_refractory_angina_with_the_coronary_sinus_Reducer
Coronary sinus reducer device for patients with refractory angina
Cardiovascular Medicine
Peter C. Kahr, Andreas A. Giannopoulos, Ronny R. Buechel, Oliver Gaemperli, Shmuel Banai, Slayman Obeid, Thomas F. Lüscher
Published: April 2018
DOI: https://doi.org/10.4414/cvm.2018.00553
Coronary Sinus Reducer implantation improves symptoms, ischaemia and physical capacity in patients with refractory angina unsuitable for myocardial revascularization: a single-center experience
EuroIntervention
Maayan Konigstein*, MD; Samuel Bazan, MD; Miri Revivo, MHA; Shmuel Banai, MD
Published July 2018
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Coronary Sinus Reducer Implantation for the Treatment of Chronic Refractory Angina – A Single-Center Experience
JACC: Cardiovascular Interventions
Francesco Giannini, Luca Baldetti, Francesco Ponticelli, Neil Ruparelia, Satoru Mitomo, Azeem Latib, Matteo Montorfano, Richard J. Jabbour, Andrea Aurelio, Luca Ferri, Antonio Mangieri, Damiano Regazzoli, Marco Ancona, Matteo Pagnesi, Alessia Faccini, Alaide Chieffo, Lorenzo Azzalini, Mauro Carlino and Antonio Colombo
Published April 2018
PDF Article
Intermittent Coronary Sinus Occlusion After Coronary Arterial Ligation Results in Venous Retroperfusion
Circulation Research
Rafael Beyar, Alan D. Guerci, Henry R. Halperin, Joshua E. Tsitlik, and Myron L. Weisfeldt
Published September 1989
https://www.ahajournals.org/doi/pdf/10.1161/01.res.65.3.695
Coronary sinus perforation during reducer implantation (Abstract)
Catheterization Cardiovascular Interventions
Bernardo Cortese MD, Gaetano di Palma MD, Roberto Latini MD
Published February 2018
https://doi.org/10.1002/ccd.27549
The coronary sinus Reducer device for refractory chronic angina: rationale, clinical evidence and future perspectives (Editorial)
Expert Review of Medical Devices
Rocco A. Montone, Michele Russo, Francesco Giannini & Giampaolo Niccoli
Published September 2018
https://doi.org/10.1080/17434440.2018.1511422
Can we implant left ventricle pacing lead in a patient with coronary sinus reducer?
Journal of Interventional Cardiac Electrophysiology
Luca Bontempi, Francesca Vassanelli, Manuel Cerini, Lorenza Inama, Francesca Salghetti, Daniele Giacopelli, Antonio Curnis
Published January 2018
https://link.springer.com/article/10.1007/s10840-017-0300-4
Coronary sinus reducer non-responders: insights and perspectives
EuroIntervention
Luca Baldetti, MD; Antonio Colombo, MD; Shmuel Banai, MD; Azeem Latib, MD; Antonio Esposito, MD; Anna Palmisano, MD; Francesco Giannini, MD
Published February 2018
https://www.pcronline.com/eurointervention/ahead-of-print/JAA_EIJ_EIJ-D-17-00626/coronary-sinus-reducer-non-responders-insights-and-perspectives.html
Reducer, extracorporeal shockwave therapy or stem cells in refractory angina: a retrospective study
Journal of Cardiovascular Medicine
Slavich, Massimo; Giannini, Francesco; Godino, Cosmo; Pizzetti, Giuseppe; Gramegna, Mario; Fragasso, Gabriele; Margonato, Alberto
Published January 2018
https://journals.lww.com/jcardiovascularmedicine/Citation/2018/01000/Reducer,_extracorporeal_shockwave_therapy_or_stem.10.aspx
First Experience With the Coronary Sinus Reducer System for the Management of Refractory Angina in Patients Without Obstructive Coronary Artery Disease
JACC: Cardiovascular Interventions- Research Correspondence
Francesco Giannini, Luca Baldetti, Alfonso Ielasi, Neil Ruparelia, Francesco Ponticelli, Azeem Latib, Satoru Mitomo, Antonio Esposito, Anna Palmisano, Alaide Chieffo and Antonio Colombo
Published September 2017
PDF Article
Implantation of the Reducer device in the coronary sinus: a new treatment for refractory angina
Giornale Italiano di Cardiologia
Francesco Giannini, Andrea Aurelio, Alaide Chieffo
Published October 2016
https://www.readbyqxmd.com/read/27729662/-coronary-sinus-reducer-implantation-a-new-treatment-for-chronic-refractory-angina
Safety and efficacy of a device to narrow the coronary sinus for the treatment of refractory angina: A single-centre real-world experience (Abstract)
Netherlands Heart Journal
Published June 2016
DOI: 10.1007/s12471-016-0862-2
Coronary Sinus Reducer improves angina and ischaemia by redistribution of blood from non-ischaemic to ischaemic myocardium (Abstract)
EuroIntervention
Konigstein M, Meyten N, Verheye S, Schwartz M, Banai S
Published October 2015
https://www.ncbi.nlm.nih.gov/pubmed/26814332
Innovative therapies for the treatment of refractory angina: the Reducer, a percutaneous device for narrowing the venous coronary sinus
Giornale Italiano di Cardiologia
Daniela Benedetto, Masieh Abawi, Pieter R. Star, Freek Nijhoff, Pierfrancesco Agostoni
Published November 2015
https://www.readbyqxmd.com/read/26571476/-innovative-therapies-for-the-treatment-of-refractory-angina-the-reducer-a-percutaneous-device-to-narrow-the-coronary-sinus
Transcatheter treatment for refractory angina with the coronary sinus Reducer
EuroIntervention
Maayan Konigstein, MD; Nathalie Meyten, MD; Stefan Verheye, MD; Marc Schwartz, RCIS; Shmuel Banai, MD
Published February 2014
https://europepmc.org/abstract/med/24561732
Coronary Sinus Reducer Implantation
Potential New Horizons Where it Should Be Tested
JACC Cardiovascular Interventions- Letter to the Editor
Iñigo Lozano, Esmeralda Capin, Dae-Hyun Lee Hwang, Ramon Lopez-Palop and Eduardo Segovia
Published August 2018
http://interventions.onlinejacc.org/content/jint/11/16/1658.1.full.pdf?download=true
Unusual Implantation of a Coronary Sinus Reducer in the Middle Cardiac Vein
Journal of Invasive Cardiology
Riccardo Gorla, MD, PhD; Francesco Giannini, MD; Francesco Bedogni, MD; Federico De Marco, MD, PhD
Published August 2018
https://www.invasivecardiology.com/articles/unusual-implantation-coronary-sinus-reducer-middle-cardiac-vein
Coronary sinus reducer for the treatment of refractory angina
International Journal of Cardiology
Ouyang F, He Y, Guo S, Wang C, Liu W, Guo Y
Published February 2019
https://www.sciencedirect.com/search?qs=Coronary%20sinus%20reducer%20for%20the%20treatment%20of%20refractory%20angina&authors=Ouyang&pub=International%20Journal%20of%20Cardiology&cid=271057&show=25&sortBy=relevance
First-in-Human Use of Coronary Sinus Reducer in Patients With Refractory Angina
Journal of the American College of Cardiology
Parikh P, Bhatt P, Shah D, Thakar P, Naik A, Baxi H, Banai S, Parikh K.
Published December 2018
http://www.onlinejacc.org/content/accj/72/24/3227.full.pdf?download=true
The coronary sinus Reducer: a new opportunity for refractory angina. Comparison between Italian experiences
Giornale Italiano di Cardiologia
Tebaldi M, Bertini M, Ielasi A, Erriquez A, Baldetti L, Passarini G, Tespili M, Gallone G, Giannini F.
Published December 2018
https://www.researchgate.net/publication/329759808_Coronary_sinus_reduction_A_new_opportunity_in_the_treatment_of_refractory_angina_Italian_experiences_compared
Percutaneous management of periprocedural coronary sinus Reducer migration
Catheterization Cardiovascular Interventions
Tzanis G, Durante A, Mitomo S, Giannini F.
Published November 2018
https://onlinelibrary.wiley.com/doi/abs/10.1002/ccd.28013
Coronary Sinus Reducer Implantation to Reduce the Ischemic Burden in Refractory Angina
JACC: Cardiovascular Interventions
Guglielmo Gallone, Luca Baldetti, Anna Palmisano, Francesco Ponticelli, Georgios Tzanis, Antonio Colombo, Antonio Esposito and Francesco Giannini
November 2018
Reviews
The Reducer device in patients with angina pectoris: mechanisms, indications, and perspectives
European Heart Journal
Maayan Konigstein Department of Cardiology, Tel-Aviv Medical Center, Tel-Aviv, Israel and the Sackler Faculty of Medicine, Tel-Aviv University, 6 Weizman Street, Tel Aviv 64239, Israel
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Maayan Konigstein,
Francesco GianniniUnit of Cardiovascular Interventions, IRCCS San Raffaele Scientific Institute, Via Olgettina Milano 60, 20132, Milan, Italy
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Francesco Giannini,
Shmuel Banai Department of Cardiology, Tel-Aviv Medical Center, Tel-Aviv, Israel and the Sackler Faculty of Medicine, Tel-Aviv University, 6 Weizman Street, Tel Aviv 64239, Israel
Corresponding author. Tel: +972?3?6973395, Fax: +972?3?6962334, Emails: banais@netvision.net.il; shmuelb@tlvmc.gov.il
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Shmuel Banai
Published August 2017
https://doi.org/10.1093/eurheartj/ehx486
The efficacy of coronary sinus reducer in patients with refractory angina—A systematic review of the literature
Journal of Interventional Cardiology
George Bazoukis MD, MSc, Emmanouil S. Brilakis MD, PhD, Gary Tse MD, PhD, Konstantinos P. Letsas MD, PhD, Panagiotis Kitsoulis MD, PhD, Tong Liu MD, PhD, Adrian Baranchuk MD, PhD, Antonios Sideris MD, Costas Tsioufis MD, PhD, Stavros Stavrakis MD, PhD
Published September 2018
https://doi.org/10.1111/joic.12560
The coronary sinus reducer: clinical evidence and technical aspects
Expert Review of Cardiovascular Therapy
Francesco Giannini, Andrea Aurelio, Richard J. Jabbour, Luca Ferri, Antonio Colombo, & Azeem Latib
Published January 2017
https://doi.org/10.1080/14779072.2017.1270755
Coronary Sinus Reducer system™: A new therapeutic option in refractory angina patients unsuitable for revascularization
International Journal of Cardiology
Alfonso Lelasi, Maria Chiara Todaro, Giulietta Grigis, Maurizio Tespili
Published April 2016
https://www.internationaljournalofcardiology.com/article/S0167-5273(16)30230-3/fulltext
Coronary Sinus Stent: Could It Help in Refractory Chronic Stable Angina?
Current Cardiology Reports
Wael ElMallah
Published April 2016
https://link.springer.com/article/10.1007%2Fs11886-016-0710-4
Percutaneous Device to Narrow the Coronary Sinus: Shifting Paradigm in the Treatment of Refractory Angina? A Review of the Literature
Frontiers in Cardiovascular Medicine
Daniela Benedetto, Masieh Abawi, Pieter R. Stella, Freek Nijhoff, Maxime D. M. Lakemeier, Friso Kortlandt, Pieter A. Doevendans, and Pierfrancesco Agostoni
Published October 2016
https://www.frontiersin.org/articles/10.3389/fcvm.2016.00042/full
THE CORONARY SINUS REDUCER: A DEVICE-BASED THERAPY FOR REFRACTORY ANGINA
Harefuah Konigstein, M; Banai S.
Published July 2017
https://www.researchgate.net/publication/326879068_THE_CORONARY_SINUS_REDUCER_A_DEVICE-BASED_THERAPY_FOR_REFRACTORY_ANGINA
In Press
Revista Española de Cardiología
Myocardial Ischemia Amelioration Reducing Venous Outflow
Zamora E., Teis A., Rodriguez O.
Published November 2018 (available online)
https://doi.org/10.1016/j.rec.2018.10.004
The impact of coronary sinus narrowing on diastolic function in patients with refractory angina
International Journal of Cardiology
Yishay Szekely, Yan Topilsky, Samuel Bazan, Miri Revivo, Shmuel Banai, Maayan Konigstein
Published March 2019 (available online)
https://doi.org/10.1016/j.ijcard.2019.03.041