Pre-Clinical
Coronary sinus reducer for the treatment of chronic refractory angina pectoris
Results of the preclinical safety and feasibility study
Catheterization and Cardiovascular Interventions
Maayan Konigstein MD, Rona Shofti DVM, PhD, Marc Schwartz RCIS, Shmuel Banai MD
Published September 2018
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First-In-Human
Coronary Sinus Reducer Stent for the Treatment of Chronic Refractory Angina Pectoris
A Prospective, Open-Label, Multicenter, Safety Feasibility First-in-Man Study
Journal of the American College of Cardiology
Shmuel Banai, Shmuel Ben Muvhar, Keyur H. Parikh, Aharon Medina, Horst Sievert, Ashok Seth, Jonathan Tsehori, Yoav Paz, Ami Sheinfeld and Gad Keren
Published May 2007
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First-in-Human Use of Coronary Sinus Reducer in Patients With Refractory Angina
Journal of the American College of Cardiology
Parth Parikh, Parloop Bhatt, Deepa Shah, Piyush Thakar, Ajay Naik, Hemang Baxi, Shmuel Banai and Keyur Parikh
Published December 2018
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Multicenter Randomized Sham-Controlled Clinical Trial
A phase II, sham-controlled, double-blinded study testing the safety and efficacy of the coronary sinus reducer in patients with refractory angina: study protocol for a randomized controlled trial
Trials
E Marc Jolicœur, Shmuel Banai, Timothy D Henry, Marc Schwartz, Serge Doucet, Christopher J White, Elazer Edelman and Stefan Verheye
Published February 2013
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Efficacy of a Device to Narrow the Coronary Sinus in Refractory Angina
New England Journal of Medicine
Stefan Verheye, M.D., Ph.D., E. Marc Jolicœur, M.D., Miles W. Behan, M.D., Thomas Pettersson, M.D., Paul Sainsbury, M.D., Jonathan Hill, M.D., Mathias Vrolix, M.D., Pierfrancesco Agostoni, M.D., Thomas Engstrom, M.D., Marino Labinaz, M.D., Ranil de Silva, M.D., Marc Schwartz, R.C.I.S., Nathalie Meyten, M.D., Neal G. Uren, M.D., Serge Doucet, M.D., Jean-François Tanguay, M.D., Steven Lindsay, M.D., Timothy D. Henry, M.D., Christopher J. White, M.D., Elazer R. Edelman, M.D., Ph.D., and Shmuel Banai, M.D.
Published February 2015
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Clinical Reports and Clinical Experience
Safety and Efficacy of Coronary Sinus Reducer Implantation at 2-year Follow-Up
International Journal of Cardiology
Francesco Ponticelli, Giorgos Tzanis, Guglielmo Gallone, Luca Baldettia, Antonio Mangieric, Antonio Colombo, Francesco Giannini
Published May 2019
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Transcatheter treatment for refractory angina with the coronary sinus Reducer
EuroIntervention
Maayan Konigstein, MD; Nathalie Meyten, MD; Stefan Verheye, MD; Marc Schwartz, RCIS; Shmuel Banai, MD
Published February 2014
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Coronary sinus reducer device for patients with refractory angina
Cardiovascular Medicine
Peter C. Kahr, Andreas A. Giannopoulos, Ronny R. Buechel, Oliver Gaemperli, Shmuel Banai, Slayman Obeid, Thomas F. Lüscher
Published: April 2018
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Coronary Sinus Reducer implantation improves symptoms, ischaemia and physical capacity in patients with refractory angina unsuitable for myocardial revascularization: a single-center experience
EuroIntervention
Maayan Konigstein, MD; Samuel Bazan, MD; Miri Revivo, MHA; Shmuel Banai, MD
Published July 2018
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Coronary Sinus Reducer Implantation for the Treatment of Chronic Refractory Angina – A Single-Center Experience
JACC: Cardiovascular Interventions
Francesco Giannini, Luca Baldetti, Francesco Ponticelli, Neil Ruparelia, Satoru Mitomo, Azeem Latib, Matteo Montorfano, Richard J. Jabbour, Andrea Aurelio, Luca Ferri, Antonio Mangieri, Damiano Regazzoli, Marco Ancona, Matteo Pagnesi, Alessia Faccini, Alaide Chieffo, Lorenzo Azzalini, Mauro Carlino and Antonio Colombo
Published April 2018
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Intermittent Coronary Sinus Occlusion After Coronary Arterial Ligation Results in Venous Retroperfusion
Circulation Research
Rafael Beyar, Alan D. Guerci, Henry R. Halperin, Joshua E. Tsitlik, and Myron L. Weisfeldt
Published September 1989
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Coronary sinus perforation during reducer implantation (Abstract)
Catheterization Cardiovascular Interventions
Bernardo Cortese MD, Gaetano di Palma MD, Roberto Latini MD
Published February 2018
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The coronary sinus Reducer device for refractory chronic angina: rationale, clinical evidence and future perspectives (Editorial)
Expert Review of Medical Devices
Rocco A. Montone, Michele Russo, Francesco Giannini & Giampaolo Niccoli
Published September 2018
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Can we implant left ventricle pacing lead in a patient with coronary sinus reducer?
Journal of Interventional Cardiac Electrophysiology
Luca Bontempi, Francesca Vassanelli, Manuel Cerini, Lorenza Inama, Francesca Salghetti, Daniele Giacopelli, Antonio Curnis
Published January 2018
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Coronary sinus reducer non-responders: insights and perspectives
EuroIntervention
Luca Baldetti, MD; Antonio Colombo, MD; Shmuel Banai, MD; Azeem Latib, MD; Antonio Esposito, MD; Anna Palmisano, MD; Francesco Giannini, MD
Published February 2018
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Reducer, extracorporeal shockwave therapy or stem cells in refractory angina: a retrospective study
Journal of Cardiovascular Medicine
Slavich, Massimo; Giannini, Francesco; Godino, Cosmo; Pizzetti, Giuseppe; Gramegna, Mario; Fragasso, Gabriele; Margonato, Alberto
Published January 2018
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First Experience With the Coronary Sinus Reducer System for the Management of Refractory Angina in Patients Without Obstructive Coronary Artery Disease
JACC: Cardiovascular Interventions- Research Correspondence
Francesco Giannini, Luca Baldetti, Alfonso Ielasi, Neil Ruparelia, Francesco Ponticelli, Azeem Latib, Satoru Mitomo, Antonio Esposito, Anna Palmisano, Alaide Chieffo and Antonio Colombo
Published September 2017
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Implantation of the Reducer device in the coronary sinus: a new treatment for refractory angina
Giornale Italiano di Cardiologia
Francesco Giannini, Andrea Aurelio, Alaide Chieffo
Published October 2016
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Safety and efficacy of a device to narrow the coronary sinus for the treatment of refractory angina: A single-centre real-world experience (Abstract)
Netherlands Heart Journal
Abawi, F. Nijhoff, P.R. Stella, M. Voskuil, D. Benedetto, P.A. Doevendans, and P. Agostoni
Published June 2016
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Coronary Sinus Reducer improves angina and ischaemia by redistribution of blood from non-ischaemic to ischaemic myocardium (Abstract)
EuroIntervention
Konigstein M, Meyten N, Verheye S, Schwartz M, Banai S
Published October 2015
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Innovative therapies for the treatment of refractory angina: the Reducer, a percutaneous device for narrowing the venous coronary sinus
Giornale Italiano di Cardiologia
Daniela Benedetto, Masieh Abawi, Pieter R. Star, Freek Nijhoff, Pierfrancesco Agostoni
Published November 2015
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Transcatheter treatment for refractory angina with the coronary sinus Reducer
EuroIntervention
Maayan Konigstein, MD; Nathalie Meyten, MD; Stefan Verheye, MD; Marc Schwartz, RCIS; Shmuel Banai, MD
Published February 2014
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Coronary Sinus Reducer Implantation
Potential New Horizons Where it Should Be Tested
JACC Cardiovascular Interventions- Letter to the Editor
Iñigo Lozano, Esmeralda Capin, Dae-Hyun Lee Hwang, Ramon Lopez-Palop and Eduardo Segovia
Published August 2018
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Unusual Implantation of a Coronary Sinus Reducer in the Middle Cardiac Vein
Journal of Invasive Cardiology
Riccardo Gorla, MD, PhD; Francesco Giannini, MD; Francesco Bedogni, MD; Federico De Marco, MD, PhD
Published August 2018
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Coronary sinus reducer for the treatment of refractory angina
International Journal of Cardiology
Ouyang F, He Y, Guo S, Wang C, Liu W, Guo Y
Published February 2019
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The coronary sinus Reducer: a new opportunity for refractory angina. Comparison between Italian experiences
Giornale Italiano di Cardiologia
Tebaldi M, Bertini M, Ielasi A, Erriquez A, Baldetti L, Passarini G, Tespili M, Gallone G, Giannini F.
Published December 2018
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Percutaneous management of periprocedural coronary sinus Reducer migration
Catheterization Cardiovascular Interventions
Tzanis G, Durante A, Mitomo S, Giannini F.
Published November 2018
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Coronary Sinus Reducer Implantation to Reduce the Ischemic Burden in Refractory Angina
JACC: Cardiovascular Interventions
Guglielmo Gallone, Luca Baldetti, Anna Palmisano, Francesco Ponticelli, Georgios Tzanis, Antonio Colombo, Antonio Esposito and Francesco Giannini
November 2018
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“Angina pectoris? A new method for patients with circulatory disorders of the heart ”
Herz Heute
Prof. Tanja Rudolph
Published February 2019
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Angina and left ventricular dysfunction: can we ‘reduce’ it?
European Society of Cardiology
Simone Biscaglia, Matteo Tebaldi, Donato Mele, Cristina Balla, and Roberto Ferrari
Published April 2019
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The coronary sinus reducer: a validate option for “no-option” labeled patients. Clinical evidences and new perspectives
Revista Argentina de Cardioangiología Intervencionista
Michele Bellamoli, Carlo Zivelonghi, Federico Marin, Flavio L. Ribichini, Stefan Verheye, Pierfrancesco Agostoni
Published March 2019
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Reviews
Refractory Angina, From Pathophysiology to New Therapeutic Nonpharmacological Technologies
JACC: Cardiovascular Interventions
Guglielmo Gallone, Luca Baldetti, Georgios Tzanis, Mario Gramegna, Azeem Latib, Antonio Colombo Timothy D. Henry, Francesco Giannini
Published January 2020
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Safety and efficacy of Coronary Sinus Reducer implantation at 2-year follow-up(Abstract, Reply to letter to the Editor)
International Journal of Cardiology
Francesco Ponticelli, Giorgos Tzanis, Guglielmo Gallone, Luca Baldettia, Antonio Mangieric, Antonio Colombo, Francesco Giannini
Published October 2019
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The Reducer device in patients with angina pectoris: mechanisms, indications, and perspectives
European Heart Journal
Maayan Konigstein, Francesco Giannini, Shmuel Banai
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The efficacy of coronary sinus reducer in patients with refractory angina—A systematic review of the literature
Journal of Interventional Cardiology
George Bazoukis MD, MSc, Emmanouil S. Brilakis MD, PhD, Gary Tse MD, PhD, Konstantinos P. Letsas MD, PhD, Panagiotis Kitsoulis MD, PhD, Tong Liu MD, PhD, Adrian Baranchuk MD, PhD, Antonios Sideris MD, Costas Tsioufis MD, PhD, Stavros Stavrakis MD, PhD
Published September 2018
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The coronary sinus reducer: clinical evidence and technical aspects
Expert Review of Cardiovascular Therapy
Francesco Giannini, Andrea Aurelio, Richard J. Jabbour, Luca Ferri, Antonio Colombo, & Azeem Latib
Published January 2017
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Coronary Sinus Reducer system™: A new therapeutic option in refractory angina patients unsuitable for revascularization
International Journal of Cardiology
Alfonso Lelasi, Maria Chiara Todaro, Giulietta Grigis, Maurizio Tespili
Published April 2016
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Coronary Sinus Stent: Could It Help in Refractory Chronic Stable Angina?
Current Cardiology Reports
Wael ElMallah
Published April 2016
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Percutaneous Device to Narrow the Coronary Sinus: Shifting Paradigm in the Treatment of Refractory Angina? A Review of the Literature
Frontiers in Cardiovascular Medicine
Daniela Benedetto, Masieh Abawi, Pieter R. Stella, Freek Nijhoff, Maxime D. M. Lakemeier, Friso Kortlandt, Pieter A. Doevendans, and Pierfrancesco Agostoni
Published October 2016
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THE CORONARY SINUS REDUCER: A DEVICE-BASED THERAPY FOR REFRACTORY ANGINA
Harefuah
Konigstein, M; Banai S.
Published July 2017
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Refractory Angina: the Current State of Mechanical Therapies (abstract)
Current Cardiology Reports
Amod Amritphale, Nupur Amritphale
Published: April 2019 (online)
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New Advances In The Management Of Refractory Angina Pectoris
European Cardiology Review
Kevin Cheng, Ranil de Silva
Published: August 2018
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Management of Refractory Angina Pectoris
European Cardiology Review
Kevin Cheng, Paul Sainsbury, Michael Fisher, Ranil de Silva
Published: December 2016
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Cost-effectiveness of the coronary sinus Reducer and its impact on the healthcare burden of refractory angina patients.
European Heart Journal – Quality of Care and Clinical Outcomes
Gallone G, Armeni P, Verheye S, Agostoni P, Timmers L, Campo G, Lelasi A, Sgura F, Tarantini G, Rosseel L, Zivelonghi C, Leenders G, Stella P, Tebaldi M, Tespili M, D’Amico G, Baldetti L, Ponticelli F, Colombo A, Giannini F
Published: May 2019
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Incomplete coronary sinus reducer endothelialization as potential mechanism of clinical failure
Catheterization and Cardiovascular Interventions
Carlo Zivelonghi MD, Gaelle Vermeersch MD, Stefan Verheye MD, PhD, Pierfrancesco Agostoni MD, PhD
Published: March 2019
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The coronary sinus reducer system for the treatment of patients with refractory angina: a single centre UK experience
Cardiology & Cardiovascular Medicine Journal
Ali N., Patel PA, Jamil H, Waleed M, Thapar S, Lindsay SJ, Sainsbury PA
Published: May 2018
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Technical aspects in Coronary Sinus Reducer implantation
EuroIntervention
Giannini F., Tzanis G., Ponticelli F., Baldetti L., Demir O.M., Mitomo S., Gallone G., Banai S., Colombo A.
Published: April 2019
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The impact of the coronary sinus reducer upon left ventricular function in patients with refractory angina pectoris
Catheterization & Cardiovascular Interventions
Georgios Tzanis MD, Anna Palmisano MD, Guglielmo Gallone MD, Francesco Ponticelli MD, Luca Baldetti MD, Antonio Esposito MD, Antonio Colombo MD, Francesco Giannini MD
Published August 2019 (online)
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Improved myocardial function with coronary sinus Reducer in a patient with refractory angina and heart failure with reduced ejection fraction
Canadian Journal of Cardiology
Guglielmo Gallone MD, Anna Palmisano MD, Luca Baldetti MD, Caterina Beatrice Monti, Francesco Ponticelli MD, Giorgos Tzanis MD, Antonio Colombo MD, Antonio Esposito MD,
Francesco Giannini MD
Published October 2019
In Press
Myocardial Ischemia Amelioration Reducing Venous Outflow
Revista Española de Cardiología
Zamora E., Teis A., Rodriguez O.
Published November 2018 (available online)
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The impact of coronary sinus narrowing on diastolic function in patients with refractory angina
International Journal of Cardiology
Yishay Szekely, Yan Topilsky, Samuel Bazan, Miri Revivo, Shmuel Banai, Maayan Konigstein
Published March 2019 (available online)
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Safety and efficacy of Coronary Sinus Reducer implantation at 2-year follow-up
International Journal of Cardiology
Francesco Ponticellia, Giorgos Tzanisa, Guglielmo Galloneb, Luca Baldettia, Antonio Mangieric, Antonio Colombo, Francesco Giannini
Published May 2019 (available online)
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